Evidence against roles for phorbol binding protein Munc13-1, ADAM adaptor Eve-1, or vesicle trafficking phosphoproteins Munc18 or NSF as phospho-state-sensitive modulators of phorbol/PKC-activated Alzheimer APP ectodomain shedding

BACKGROUND: Shedding of the Alzheimer amyloid precursor protein (APP) ectodomain can be accelerated by phorbol esters, compounds that act via protein kinase C (PKC) or through unconventional phorbol-binding proteins such as Munc13-1. We have previously demonstrated that application of phorbol esters...

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Hauptverfasser: Ikin, Annat F, Causevic, Mirsada, Pedrini, Steve, Benson, Lyndsey S, Buxbaum, Joseph D, Suzuki, Toshiharu, Lovestone, Simon, Higashiyama, Shigeki, Mustelin, Tomas, Burgoyne, Robert D, Gandy, Sam
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2007
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211485/
https://ncbi.nlm.nih.gov/pubmed/18067682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-2-23
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