Modulation of Statin-Activated Shedding of Alzheimer APP Ectodomain by ROCK

BACKGROUND: Statins are widely used cholesterol-lowering drugs that act by inhibiting HMGCoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. Recent evidence suggests that statin use may be associated with a decreased risk for Alzheimer disease, although the mechanisms underlying thi...

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Bibliografiske detaljer
Main Authors: Pedrini, Steve, Carter, Troy L, Prendergast, George, Petanceska, Suzana, Ehrlich, Michelle E, Gandy, Sam
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2005
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC543463/
https://ncbi.nlm.nih.gov/pubmed/15647781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0020018
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