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Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications

Prenatal nutritional constraint induces an altered metabolic phenotype in the offspring which in humans confers an increased risk of non-communicable disease. Feeding a protein-restricted (PR) diet to pregnant rats causes hypomethylation of specific gene promoters in the offspring and alters phenoty...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Lillycrop, Karen A, Slater-Jefferies, Jo L, Hanson, Mark A, Godfrey, Keith M, Jackson, Alan A, Burdge, Graham C
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2007
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211425/
https://ncbi.nlm.nih.gov/pubmed/17433129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S000711450769196X
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