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Dietary protein restriction of pregnant rats in the F(0) generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F(1) and F(2) generations

Epidemiological studies and experimental models show that maternal nutritional constraint during pregnancy alters the metabolic phenotype of the offspring and that this can be passed to subsequent generations. In the rat, induction of an altered metabolic phenotype in the liver of the F(1) generatio...

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Detalhes bibliográficos
Main Authors: Burdge, Graham C., Slater-Jefferies, Jo, Torrens, Christopher, Phillips, Emma S., Hanson, Mark A., Lillycrop, Karen A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211514/
https://ncbi.nlm.nih.gov/pubmed/17313703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S0007114507352392
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