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Feeding a protein-restricted diet during pregnancy induces altered epigenetic regulation of peroxisomal proliferator-activated receptor-α in the heart of the offspring

Impaired flexibility in the use of substrates for energy production in the heart is implicated in cardiomyopathy. We investigated the effect of maternal protein restriction during pregnancy in rats on the transcription of key genes in cardiac lipid and carbohydrate metabolism in the offspring. Rats...

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Main Authors: Slater-Jefferies, J.L., Lillycrop, K.A., Townsend, P.A., Torrens, C., Hoile, S.P., Hanson, M.A., Burdge, G.C.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191520/
https://ncbi.nlm.nih.gov/pubmed/22003431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S2040174410000425
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