Instability of retroviral vectors with HIV-1-specific RT aptamers due to cryptic splice sites in the U6 promoter

BACKGROUND: Internal polymerase III promoters in retroviral vectors have been used extensively to express short RNA sequences, such as ribozymes, RNA aptamers or short interfering RNA inhibitors, in various positions and orientations. However, the stability of these promoters in the reverse orientat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Braun, Stephen E, Shi, Xuanling, Qiu, Gang, Wong, Fay Eng, Joshi, Pheroze J, Prasad, Vinayaka R, Johnson, R Paul
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2007
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211285/
https://ncbi.nlm.nih.gov/pubmed/17941994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-6405-4-24
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge