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Instability of retroviral vectors with HIV-1-specific RT aptamers due to cryptic splice sites in the U6 promoter

BACKGROUND: Internal polymerase III promoters in retroviral vectors have been used extensively to express short RNA sequences, such as ribozymes, RNA aptamers or short interfering RNA inhibitors, in various positions and orientations. However, the stability of these promoters in the reverse orientat...

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מידע ביבליוגרפי
Main Authors: Braun, Stephen E, Shi, Xuanling, Qiu, Gang, Wong, Fay Eng, Joshi, Pheroze J, Prasad, Vinayaka R, Johnson, R Paul
פורמט: Artigo
שפה:Inglês
יצא לאור: BioMed Central 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211285/
https://ncbi.nlm.nih.gov/pubmed/17941994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-6405-4-24
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