Instability of retroviral vectors with HIV-1-specific RT aptamers due to cryptic splice sites in the U6 promoter

BACKGROUND: Internal polymerase III promoters in retroviral vectors have been used extensively to express short RNA sequences, such as ribozymes, RNA aptamers or short interfering RNA inhibitors, in various positions and orientations. However, the stability of these promoters in the reverse orientat...

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Hlavní autoři: Braun, Stephen E, Shi, Xuanling, Qiu, Gang, Wong, Fay Eng, Joshi, Pheroze J, Prasad, Vinayaka R, Johnson, R Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2007
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211285/
https://ncbi.nlm.nih.gov/pubmed/17941994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-6405-4-24
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