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Significance of mutations on the structural perturbation of thymidylate synthase: Implications for their involvement in subunit exchange
Wild-type thymidylate synthase (WT-TS) from Escherichia coli and several of its mutants showed varying degrees of susceptibility to trypsin. While WT-TS was resistant to trypsin as were the mutants C146S, K48E, and R126K, others such as Y94A, Y94F, C146W, and R126E were digested but at different rat...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2206691/ https://ncbi.nlm.nih.gov/pubmed/17586776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.062509807 |
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