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Metrics of sequence constraint overlook regulatory sequences in an exhaustive analysis at phox2b

Despite its recognized utility, the extent to which evolutionary sequence conservation-based approaches may systematically overlook functional noncoding sequences remains unclear. We have tiled across sequence encompassing the zebrafish phox2b gene, ultimately evaluating 48 amplicons corresponding t...

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Detalhes bibliográficos
Main Authors: McGaughey, David M., Vinton, Ryan M., Huynh, Jimmy, Al-Saif, Amr, Beer, Michael A., McCallion, Andrew S.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203623/
https://ncbi.nlm.nih.gov/pubmed/18071029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.6929408
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