Non-detectable levels of 6-thioguanine nucleotides and 6-methylmercaptopurine in a patient treated with azathioprine: a case report

INTRODUCTION: Azathioprine (AZA) is a thiopurine prodrug clinically used for immunosuppression in the treatment of auto-immune inflammatory diseases and in regimens of organ transplantations. The pharmacological action of AZA is based on the formation of 6-mercaptopurine (6-MP), which is metabolised...

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Autors principals: Wong, D R, den Dulk, M O, Derijks, L J J, Gemmeke, E H K M, Hooymans, P M
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Publishing Ltd 2007
Matèries:
Proceedings of the Dutch Society of Clinical Pharmacology and Biopharmacy meeting of September 27th 2006
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2203228/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02886_10.x
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