6-Thioguanine in children with acute lymphoblastic leukaemia: influence of food on parent drug pharmacokinetics and 6-thioguanine nucleotide concentrations

AIMS: Since relatively little is known about the pharmacokinetics of 6-thioguanine (6TG) in children receiving 6-thioguanine for maintenance therapy of acute lymphoblastic leukaemia (ALL), we studied plasma drug concentrations under standardized conditions and investigated the effect of food on pare...

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Autors principals: Lancaster, D L, Patel, N, Lennard, L, Lilleyman, J S
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2001
Matèries:
Pharmacokinetics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2014483/
https://ncbi.nlm.nih.gov/pubmed/11422012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.0306-5251.2001.01391.x
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