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Mercaptopurine in childhood leukaemia: the effects of dose escalation on thioguanine nucleotide metabolites

The current U.K. trial protocol (UKALL XI) for childhood lymphoblastic leukaemia demands mercaptopurine (MP) dose escalation in children who tolerate daily 75 mg/m(2) MP (100% dose) without cytopenias. The previous trial (UKALL X) did not. MP metabolism was studied in a group of UKALL XI children (n...

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Detalhes bibliográficos
Main Authors: LENNARD, L., WELCH, J., LILLEYMAN, J. S.
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2042700/
https://ncbi.nlm.nih.gov/pubmed/8904630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.1996.44921.x
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