Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-γ-dependent mechanisms

Resistance to murine leishmaniasis correlates with development of a CD4(+) T helper 1 (Th1)-predominant immune response. To determine whether immunostimulatory CpG-containing oligodeoxynucleotides (CpG-ODN), known to promote a Th1 immune response, could provide protection from Leishmania infection,...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Walker, Patricia S., Scharton-Kersten, Tanya, Krieg, Arthur M., Love-Homan, Laurie, Rowton, Edgar D., Udey, Mark C., Vogel, Jonathan C.
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22026/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10359823/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.12.6970
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