Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

Unmethylated CpG dinucleotides in particular base contexts (CpG-S motifs) are relatively common in bacterial DNA but are rare in vertebrate DNA. B cells and monocytes have the ability to detect such CpG-S motifs that trigger innate immune defenses with production of Th1-like cytokines. Despite compa...

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Detalhes bibliográficos
Main Authors: Krieg, Arthur M., Wu, Tong, Weeratna, Risini, Efler, Susan M., Love-Homan, Laurie, Yang, Lin, Yi, Ae-Kyung, Short, Dan, Davis, Heather L.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC22882/
https://ncbi.nlm.nih.gov/pubmed/9770537
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