C/EBPα binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment

The PU.1 gene contains a 237–base pair distal enhancer located 14 kilobases upstream of its promoter. We have identified 2 sites within the PU.1 enhancer that strongly bind C/EBPα in a gel shift assay, and interaction with endogenous C/EBPα was confirmed by chromatin immunoprecipitation. Mutation of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Yeamans, Christine, Wang, Dehua, Paz-Priel, Ido, Torbett, Bruce E., Tenen, Daniel G., Friedman, Alan D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2007
Schlagworte:
Hematopoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200910/
https://ncbi.nlm.nih.gov/pubmed/17671233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-080291
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge