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C/EBPα binds and activates the PU.1 distal enhancer to induce monocyte lineage commitment
The PU.1 gene contains a 237–base pair distal enhancer located 14 kilobases upstream of its promoter. We have identified 2 sites within the PU.1 enhancer that strongly bind C/EBPα in a gel shift assay, and interaction with endogenous C/EBPα was confirmed by chromatin immunoprecipitation. Mutation of...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2200910/ https://ncbi.nlm.nih.gov/pubmed/17671233 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-080291 |
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