Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells

Microbial products, including lipopolysaccharide (LPS), an agonist of Toll-like receptor 4 (TLR4), regulate the lifespan of dendritic cells (DCs) by largely undefined mechanisms. Here, we identify a role for calcium-calmodulin–dependent kinase IV (CaMKIV) in this survival program. The pharmacologic...

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Autors principals: Illario, Maddalena, Giardino-Torchia, Maria L., Sankar, Uma, Ribar, Thomas J., Galgani, Mario, Vitiello, Laura, Masci, Anna Maria, Bertani, Francesca R., Ciaglia, Elena, Astone, Dalila, Maulucci, Giuseppe, Cavallo, Anna, Vitale, Mario, Cimini, Vincenzo, Pastore, Lucio, Means, Anthony R., Rossi, Guido, Racioppi, Luigi
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2008
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200860/
https://ncbi.nlm.nih.gov/pubmed/17909078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-091173
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