FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma

FTY720 is an immunosuppressant developed to prevent organ transplant rejection. Recent studies indicate an additional role for FTY720 in inducing cell apoptosis. We demonstrate here that FTY720 mediates toxic effects in cell lines representing different B-cell malignancies and primary B cells from p...

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Main Authors: Liu, Qing, Zhao, Xiaobin, Frissora, Frank, Ma, Yihui, Santhanam, Ramasamy, Jarjoura, David, Lehman, Amy, Perrotti, Danilo, Chen, Ching-Shih, Dalton, James T., Muthusamy, Natarajan, Byrd, John C.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2008
Assuntos:
Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2200813/
https://ncbi.nlm.nih.gov/pubmed/17761520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-10-053884
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