Negative Regulation of Ros Receptor Tyrosine Kinase Signaling: An Epithelial Function of the Sh2 Domain Protein Tyrosine Phosphatase Shp-1

Male “viable motheaten” (me(v)) mice, with a naturally occurring mutation in the gene of the SH2 domain protein tyrosine phosphatase SHP-1, are sterile. Known defects in sperm maturation in these mice correlate with an impaired differentiation of the epididymis, which has similarities to the phenoty...

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Bibliographic Details
Main Authors: Keilhack, Heike, Müller, Marit, Böhmer, Sylvia-Annette, Frank, Carsten, Weidner, K. Michael, Birchmeier, Walter, Ligensa, Tanja, Berndt, Alexander, Kosmehl, Hartwig, Günther, Bernd, Müller, Thomas, Birchmeier, Carmen, Böhmer, Frank D.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2001
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199605/
https://ncbi.nlm.nih.gov/pubmed/11266449
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