PI-3K/Akt Pathway-Dependent Cyclin D1 Expression Is Responsible for Arsenite-Induced Human Keratinocyte Transformation

BACKGROUND: Long-term exposure of arsenite leads to human skin cancer. However, the exact mechanisms of arsenite-induced human skin carcinogenesis remain to be defined. OBJECTIVES: In this study, we investigated the potential role of PI-3K/Akt/cyclin D1in the transformation of human keratinocytic ce...

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Detalhes bibliográficos
Main Authors: Ouyang, Weiming, Luo, Wenjing, Zhang, Dongyun, Jian, Jinlong, Ma, Qian, Li, Jingxia, Shi, Xianglin, Chen, Jingyuan, Gao, Jimin, Huang, Chuanshu
Formato: Artigo
Idioma:Inglês
Publicado em: National Institute of Environmental Health Sciences 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2199295/
https://ncbi.nlm.nih.gov/pubmed/18197291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.10403
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