T Cell Receptor (TCR)-induced Death of Immature CD4(+)CD8(+) Thymocytes by Two Distinct Mechanisms Differing in Their Requirement for CD28 Costimulation: Implications for Negative Selection in the Thymus

Antzeko izenburuak

• Regulated costimulation in the thymus is critical for T cell development: Dysregulated CD28 costimulation can bypass the pre-TCR checkpoint
  nork: Williams, Joy A., et al.
  Argitaratua: (2005)
• Lineage Commitment in the Thymus: Only the Most Differentiated (TCR(hi)bcl-2(hi)) Subset of CD4(+)CD8(+)Thymocytes Has Selectively Terminated CD4 or CD8 Synthesis
  nork: Punt, Jennifer A., et al.
  Argitaratua: (1996)
• ZAP-70 Protein Promotes Tyrosine Phosphorylation of T Cell Receptor Signaling Motifs (ITAMs) in Immature CD4(+)8(+) Thymocytes with Limiting p56(lck)
  nork: Ashe, Jennifer M., et al.
  Argitaratua: (1999)
• Commitment of Immature CD4(+)8(+) Thymocytes to the CD4 Lineage Requires CD3 Signaling but Does Not Require Expression of Clonotypic T Cell Receptor (TCR) Chains
  nork: Suzuki, Harumi, et al.
  Argitaratua: (1997)
• Immature CD8 Single-Positive Thymocytes Are a Molecularly Distinct Subpopulation, Selectively Dependent on BRD4 for Their Differentiation
  nork: Gegonne, Anne, et al.
  Argitaratua: (2018)