The pharmacokinetic profile of sitaxsentan, a selective endothelin receptor antagonist, in varying degrees of renal impairment

AIM: To investigate the pharmacokinetic profile of a single 100-mg oral dose of sitaxsentan, a selective endothelin type A receptor antagonist, in subjects with normal and impaired renal function. METHODS: This was an open label, single oral dose study in subjects with normal [creatinine clearance (...

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Main Authors: Dhaun, Neeraj, Melville, Vanessa, Kramer, William, Stavros, Fiona, Coyne, Terrance, Swan, Suzanne, Goddard, Jane, Webb, David J
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2007
Assuntos:
Pharmacokinetics in Renal Insufficiency and Dialysis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2198787/
https://ncbi.nlm.nih.gov/pubmed/17635499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2007.02979.x
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