Endothelin-A Receptor Antagonism Modifies Cardiovascular Risk Factors in CKD

Arterial stiffness and impaired nitric oxide (NO) bioavailability contribute to the high risk for cardiovascular disease in CKD. Both asymmetric dimethylarginine (ADMA), an endogenous inhibitor of NO production, and endothelin-1 (ET-1) oppose the actions of NO, suggesting that ET-1 receptor antagoni...

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Detalhes bibliográficos
Main Authors: Dhaun, Neeraj, Melville, Vanessa, Blackwell, Scott, Talwar, Dinesh K., Johnston, Neil R., Goddard, Jane, Webb, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2012
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537212/
https://ncbi.nlm.nih.gov/pubmed/23243212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012040355
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