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High resolution mapping of mast cell membranes reveals primary and secondary domains of FcεRI and LAT

In mast cells, cross-linking the high-affinity IgE receptor (FcεRI) initiates the Lyn-mediated phosphorylation of receptor ITAMs, forming phospho-ITAM binding sites for Syk. Previous immunogold labeling of membrane sheets showed that resting FcεRI colocalize loosely with Lyn, whereas cross-linked Fc...

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Detalhes bibliográficos
Main Authors: Wilson, Bridget S., Pfeiffer, Janet R., Surviladze, Zurab, Gaudet, Elizabeth A., Oliver, Janet M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196429/
https://ncbi.nlm.nih.gov/pubmed/11489921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200104049
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