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The telomerase RNA pseudoknot is critical for the stable assembly of a catalytically active ribonucleoprotein

Telomerase is a ribonucleoprotein reverse transcriptase that synthesizes telomeric DNA. A pseudoknot structure is phylogenetically conserved within the RNA component of telomerase in all ciliated protozoans examined. Here, we report that disruptions of the pseudoknot base pairing within the telomera...

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Autors principals: Gilley, David, Blackburn, Elizabeth H.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC21964/
https://ncbi.nlm.nih.gov/pubmed/10359761
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