Exploring the Recognition of Quadruplex DNA by an Engineered Cys(2)-His(2) Zinc Finger Protein

We have recently described an engineered zinc finger protein (Gq1) that binds with high specificity to the intramolecular G-quadruplex formed by the human telomeric sequence 5′-(GGTTAG)(5)-3′, and that inhibits the activity of the enzyme telomerase in vitro. Here we report site-directed mutagenesis,...

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Bibliografiske detaljer
Main Authors: Ladame, Sylvain, Schouten, James A., Roldan, Jose, Redman, James E., Neidle, Stephen, Balasubramanian, Shankar
Format: Artigo
Sprog:Inglês
Udgivet: 2006
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196205/
https://ncbi.nlm.nih.gov/pubmed/16445281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi050229x
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