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Exploring the Recognition of Quadruplex DNA by an Engineered Cys(2)-His(2) Zinc Finger Protein
We have recently described an engineered zinc finger protein (Gq1) that binds with high specificity to the intramolecular G-quadruplex formed by the human telomeric sequence 5′-(GGTTAG)(5)-3′, and that inhibits the activity of the enzyme telomerase in vitro. Here we report site-directed mutagenesis,...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2006
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2196205/ https://ncbi.nlm.nih.gov/pubmed/16445281 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi050229x |
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