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Discovery of G-quadruplex stabilizing ligands through direct ELISA of a one-bead-one-compound library
We describe the identification of small-molecule G-quadruplex ligands using a direct ELISA screen of a one-bead-one-compound library of unnatural polyamides displayed on a branched linker with a biotin tag. This general purpose parallel screen for small molecule-oligonucleotide interactions was vali...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2196204/ https://ncbi.nlm.nih.gov/pubmed/17102882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b611716c |
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