The Single Positive T Cells Found in CD3-ζ/η(−) (/−) Mice Overtly React with Self–Major Histocompatibility Complex Molecules upon Restoration of Normal Surface Density of T Cell Receptor–CD3 Complex

CD3-ζ/η–deficient mice have small thymuses containing cells that show a profound reduction in the surface levels of T cell receptors and terminate their differentiation at the CD4(+)CD8(+) stage. Rather unexpectedly, CD3(−) (or) (very) (low) single positive T cells accumulate over time in the spleen...

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Hauptverfasser: Lin, Shih-Yao, Ardouin, Laurence, Gillet, Anne, Malissen, Marie, Malissen, Bernard
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 1997
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196153/
https://ncbi.nlm.nih.gov/pubmed/9034149
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