Critical Role of the Programmed Death-1 (PD-1) Pathway in Regulation of Experimental Autoimmune Encephalomyelitis

Experimental autoimmune encephalomyelitis (EAE) is mediated by autoantigen-specific T cells dependent on critical costimulatory signals for their full activation and regulation. We report that the programmed death-1 (PD-1) costimulatory pathway plays a critical role in regulating peripheral toleranc...

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Main Authors: Salama, Alan D., Chitnis, Tanuja, Imitola, Jaime, Ansari, Mohammed Javeed I., Akiba, Hisaya, Tushima, Fumihiko, Azuma, Miyuki, Yagita, Hideo, Sayegh, Mohamed H., Khoury, Samia J.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2003
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196082/
https://ncbi.nlm.nih.gov/pubmed/12847138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20022119
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