Tryptophan-derived Catabolites Are Responsible for Inhibition of T and Natural Killer Cell Proliferation Induced by Indoleamine 2,3-Dioxygenase

Macrophages exposed to macrophage colony-stimulating factor acquire the capacity to suppress T cell proliferation; this effect is associated with de novo expression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO). We have purified IDO and tested its activity in in vitro model...

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Main Authors: Frumento, Guido, Rotondo, Rita, Tonetti, Michela, Damonte, Gianluca, Benatti, Umberto, Ferrara, Giovanni Battista
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2002
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196046/
https://ncbi.nlm.nih.gov/pubmed/12186838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020121
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