Therapeutic Activity of an Engineered Synthetic Killer Antiidiotypic Antibody Fragment against Experimental Mucosal and Systemic Candidiasis

Peptides derived from the sequence of a single-chain, recombinant, antiidiotypic antibody (IdAb; KT-scFv) acting as a functional internal image of a microbicidal, wide-spectrum yeast killer toxin (KT) were synthesized and studied for their antimicrobial activity by using the KT-susceptible Candida a...

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Detalhes bibliográficos
Main Authors: Polonelli, Luciano, Magliani, Walter, Conti, Stefania, Bracci, Luisa, Lozzi, Luisa, Neri, Paolo, Adriani, Daniela, De Bernardis, Flavia, Cassone, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC219587/
https://ncbi.nlm.nih.gov/pubmed/14573638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.71.11.6205-6212.2003
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