The HIV-1 Viral Protein R Induces Apoptosis via a Direct Effect on the Mitochondrial Permeability Transition Pore

Viral protein R (Vpr) encoded by HIV-1 is a facultative inducer of apoptosis. When added to intact cells or purified mitochondria, micromolar and submicromolar doses of synthetic Vpr cause a rapid dissipation of the mitochondrial transmembrane potential (ΔΨ(m)), as well as the mitochondrial release...

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Main Authors: Jacotot, Etienne, Ravagnan, Luigi, Loeffler, Markus, Ferri, Karine F., Vieira, Helena L.A., Zamzami, Naoufal, Costantini, Paola, Druillennec, Sabine, Hoebeke, Johan, Briand, Jean Paul, Irinopoulou, Theano, Daugas, Eric, Susin, Santos A., Cointe, Denis, Xie, Zhi Hua, Reed, John C., Roques, Bernard P., Kroemer, Guido
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2000
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195797/
https://ncbi.nlm.nih.gov/pubmed/10620603
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