Neonatal Tumor Necrosis Factor α Promotes Diabetes in Nonobese Diabetic Mice by Cd154-Independent Antigen Presentation to Cd8(+) T Cells

Neonatal islet-specific expression of tumor necrosis factor (TNF)-α in nonobese diabetic mice promotes diabetes by provoking islet-infiltrating antigen-presenting cells to present islet peptides to autoreactive T cells. Here we show that TNF-α promotes autoaggression of both effector CD4(+) and CD8(...

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Bibliographic Details
Main Authors: Green, E. Allison, Wong, F. Susan, Eshima, Koji, Mora, Conchi, Flavell, Richard A.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2000
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195753/
https://ncbi.nlm.nih.gov/pubmed/10637268
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