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The Src Family Tyrosine Kinase Fyn Regulates Natural Killer T Cell Development

T lymphocytes express two Src tyrosine kinases, Lck and Fyn. While thymocyte and T cell subsets are largely normal in fyn(−/−) mice, animals lacking Lck have impaired T cell development. Here, it is shown that Fyn is required for the rapid burst of interleukin (IL)-4 and IL-13 synthesis, which occur...

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Autores principales: Gadue, Paul, Morton, Neil, Stein, Paul L.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 1999
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2195667/
https://ncbi.nlm.nih.gov/pubmed/10523617
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