Krüppel-Like Factor 5 Mediates Cellular Transformation during Oncogenic KRAS-Induced Intestinal Tumorigenesis

BACKGROUND & AIMS: Krüppel-like factor 5 (KLF5) is a zinc finger-containing transcription factor that regulates cell proliferation. Oncogenic KRAS mutations are commonly found in colorectal cancers. We aimed to determine whether KLF5 mediates KRAS functions during intestinal tumorigenesis. METHO...

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Main Authors: Nandan, Mandayam O., McConnell, Beth B., Ghaleb, Amr M., Bialkowska, Agnieszka B., Sheng, Hongmiao, Shao, Jinyi, Babbin, Brian A., Robine, Sylvie, Yang, Vincent W.
Format: Artigo
Language:Inglês
Published: 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194652/
https://ncbi.nlm.nih.gov/pubmed/18054006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2007.10.023
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