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Modification of the ionizing radiation response in living cells by an scFv against the DNA-dependent protein kinase

The non-homologous end joining pathway uses pre-existing proteins to repair DNA double-strand breaks induced by ionizing radiation. Here we describe manipulation of this pathway in living cells using a newly developed tool. We generated a single chain antibody variable fragment (scFv) that binds to...

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Detalhes bibliográficos
Main Authors: Li, Shuyi, Takeda, Yoshihiko, Wragg, Stéphanie, Barrett, John, Phillips, Andrew, Dynan, William S.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC219464/
https://ncbi.nlm.nih.gov/pubmed/14530433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg775
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