DNA-dependent Protein Kinase Activity Is Not Required for Immunoglobulin Class Switching

Class switch recombination (CSR), similar to V(D)J recombination, is thought to involve DNA double strand breaks and repair by the nonhomologous end–joining pathway. A key component of this pathway is DNA-dependent protein kinase (DNA-PK), consisting of a catalytic subunit (DNA-PKcs) and a DNA-bindi...

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Main Authors: Bosma, Gayle C., Kim, Jiyoon, Urich, Teresa, Fath, Donna M., Cotticelli, Maria G., Ruetsch, Norman R., Radic, Marko Z., Bosma, Melvin J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194268/
https://ncbi.nlm.nih.gov/pubmed/12461083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20001871
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