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The Cellular Location of Self-antigen Determines the Positive and Negative Selection of Autoreactive B Cells
Systemic autoimmune disease is frequently characterized by the production of autoantibodies against widely expressed intracellular self-antigens, whereas B cell tolerance to ubiquitous and highly expressed extracellular antigens is strictly enforced. To test for differences in the B cell response to...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2194246/ https://ncbi.nlm.nih.gov/pubmed/14597740 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030279 |
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