The Balance Between Pax5 and Id2 Activities Is the Key to AID Gene Expression

Pax5 activity is enhanced in activated B cells and is essential for class switch recombination (CSR). We show that inhibitor of differentiation (Id)2 suppresses CSR by repressing the gene expression of activation-induced cytidine deaminase (AID), which has been shown to be indispensable for CSR. Fur...

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Hauptverfasser: Gonda, Hiroyuki, Sugai, Manabu, Nambu, Yukiko, Katakai, Tomoya, Agata, Yasutoshi, Mori, Kazuhiro J., Yokota, Yoshifumi, Shimizu, Akira
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194241/
https://ncbi.nlm.nih.gov/pubmed/14581609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030802
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