Restoration of CD28 Expression in CD28(−) CD8(+) Memory Effector T Cells Reconstitutes Antigen-induced IL-2 Production

The control of many persistent viral infections by Ag-specific cytolytic CD8(+) T cells requires a concurrent virus-specific CD4(+) Th cell response. This reflects in part a requirement of activated effector CD8(+) T cells for paracrine IL-2 production as a growth and survival factor. In human CMV a...

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Bibliographische Detailangaben
Hauptverfasser: Topp, Max S., Riddell, Stanley R., Akatsuka, Yoshiki, Jensen, Michael C., Blattman, Joseph N., Greenberg, Philip D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2003
Schlagworte:
Brief Definitive Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194206/
https://ncbi.nlm.nih.gov/pubmed/12963692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20021288
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