Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

The Vav family of Rho guanine nucleotide exchange factors is thought to orchestrate signaling events downstream of lymphocyte antigen receptors. Elucidation of Vav function has been obscured thus far by the expression of three highly related family members. We generated mice lacking all Vav family p...

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Main Authors: Fujikawa, Keiko, Miletic, Ana V., Alt, Frederick W., Faccio, Roberta, Brown, Tracie, Hoog, Jeremy, Fredericks, Jessica, Nishi, Shinzo, Mildiner, Shirly, Moores, Sheri L., Brugge, Joan, Rosen, Fred S., Swat, Wojciech
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194126/
https://ncbi.nlm.nih.gov/pubmed/14623913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030874
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