Vav1/2/3-null Mice Define an Essential Role for Vav Family Proteins in Lymphocyte Development and Activation but a Differential Requirement in MAPK Signaling in T and B Cells

The Vav family of Rho guanine nucleotide exchange factors is thought to orchestrate signaling events downstream of lymphocyte antigen receptors. Elucidation of Vav function has been obscured thus far by the expression of three highly related family members. We generated mice lacking all Vav family p...

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Main Authors: Fujikawa, Keiko, Miletic, Ana V., Alt, Frederick W., Faccio, Roberta, Brown, Tracie, Hoog, Jeremy, Fredericks, Jessica, Nishi, Shinzo, Mildiner, Shirly, Moores, Sheri L., Brugge, Joan, Rosen, Fred S., Swat, Wojciech
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194126/
https://ncbi.nlm.nih.gov/pubmed/14623913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030874
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