Contributions of the T Cell Receptor–associated CD3γ–ITAM to Thymocyte Selection

The immunoreceptor tyrosine-based activation motifs (ITAMs) in the CD3 chains associated with the T cell receptor (TCR) are crucial for TCR signaling. To probe the role of the CD3γ–ITAM in T cell development, we created knock-in mice in which the CD3γ chain of the TCR complex is replaced by a mutant...

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Autors principals: Haks, Mariëlle C., Pépin, Elsa, van den Brakel, Jeroen H.N., Smeele, Sigrid A.A., Belkowski, Stanley M., Kessels, Helmut W.H.G., Krimpenfort, Paul, Kruisbeek, Ada M.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2002
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194018/
https://ncbi.nlm.nih.gov/pubmed/12093866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020268
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