The Biological Outcome of CD40 Signaling Is Dependent on the Duration of CD40 Ligand Expression: Reciprocal Regulation by Interleukin (IL)-4 and IL-12

CD40 ligand (CD154) expression on activated T cells can be separated into an early TCR-dependent phase, which occurs between 0 and 24 h after activation, and a later extended phase, which occurs after 24 h and is reciprocally regulated by the cytokines IL-4 and IL-12. IL-4 represses, whereas IL-12 s...

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Bibliographic Details
Main Authors: Lee, Byung O., Haynes, Laura, Eaton, Sheri M., Swain, Susan L., Randall, Troy D.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2002
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2194000/
https://ncbi.nlm.nih.gov/pubmed/12208883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020845
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