Two Distinct Pathways Mediated by PA28 and hsp90 in Major Histocompatibility Complex Class I Antigen Processing

Major histocompatibility complex (MHC) class I ligands are mainly produced by the proteasome. Herein, we show that the processing of antigens is regulated by two distinct pathways, one requiring PA28 and the other hsp90. Both hsp90 and PA28 enhanced the antigen processing of ovalbumin (OVA). Geldana...

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Main Authors: Yamano, Taketoshi, Murata, Shigeo, Shimbara, Naoki, Tanaka, Noriaki, Chiba, Tomoki, Tanaka, Keiji, Yui, Katsuyuki, Udono, Heiichiro
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2002
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193925/
https://ncbi.nlm.nih.gov/pubmed/12119343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20011922
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