Degeneracy of Antigen Recognition as the Molecular Basis for the High Frequency of Naive A2/Melan-A Peptide Multimer(+) CD8(+) T Cells in Humans

In contrast with the low frequency of most single epitope reactive T cells in the preimmune repertoire, up to 1 of 1,000 naive CD8(+) T cells from A2(+) individuals specifically bind fluorescent A2/peptide multimers incorporating the A27L analogue of the immunodominant 26–35 peptide from the melanoc...

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Detalhes bibliográficos
Main Authors: Dutoit, Valérie, Rubio-Godoy, Verena, Pittet, Mikäel J., Zippelius, Alfred, Dietrich, Pierre-Yves, Legal, Frédérique Anne, Guillaume, Philippe, Romero, Pedro, Cerottini, Jean-Charles, Houghten, Richard A., Pinilla, Clemencia, Valmori, Danila
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193921/
https://ncbi.nlm.nih.gov/pubmed/12119345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20020242
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