Thymic Selection Generates a Large T Cell Pool Recognizing a Self-Peptide in Humans

The low frequency of self-peptide–specific T cells in the human preimmune repertoire has so far precluded their direct evaluation. Here, we report an unexpected high frequency of T cells specific for the self-antigen Melan-A/MART-1 in CD8 single–positive thymocytes from human histocompatibility leuk...

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Bibliographic Details
Main Authors: Zippelius, Alfred, Pittet, Mikaël J., Batard, Pascal, Rufer, Nathalie, de Smedt, Magda, Guillaume, Philippe, Ellefsen, Kim, Valmori, Danila, Liénard, Danielle, Plum, Jean, MacDonald, H. Robson, Speiser, Daniel E., Cerottini, Jean-Charles, Romero, Pedro
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2002
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193620/
https://ncbi.nlm.nih.gov/pubmed/11854361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20011658
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