The Poxvirus Protein A52R Targets Toll-like Receptor Signaling Complexes to Suppress Host Defense

Toll-like receptors (TLRs) are crucial in the innate immune response to pathogens, in that they recognize and respond to pathogen associated molecular patterns, which leads to activation of intracellular signaling pathways and altered gene expression. Vaccinia virus (VV), the poxvirus used to vaccin...

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Main Authors: Harte, Mary T., Haga, Ismar R., Maloney, Geraldine, Gray, Pearl, Reading, Patrick C., Bartlett, Nathan W., Smith, Geoffrey L., Bowie, Andrew, O'Neill, Luke A.J.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2003
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193841/
https://ncbi.nlm.nih.gov/pubmed/12566418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20021652
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