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Critical Roles of Pten in B Cell Homeostasis and Immunoglobulin Class Switch Recombination
Pten is a tumor suppressor gene mutated in human cancers. We used the Cre-loxP system to generate a B cell–specific mutation of Pten in mice (bPten (flox/flox)mice). bPten (flox/flox) mice showed elevated numbers of B1a cells and increased serum autoantibodies. Among B2 cells in bPten (flox/flox) sp...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2003
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2193827/ https://ncbi.nlm.nih.gov/pubmed/12615906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20021101 |
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