Critical Roles of Pten in B Cell Homeostasis and Immunoglobulin Class Switch Recombination

Pten is a tumor suppressor gene mutated in human cancers. We used the Cre-loxP system to generate a B cell–specific mutation of Pten in mice (bPten (flox/flox)mice). bPten (flox/flox) mice showed elevated numbers of B1a cells and increased serum autoantibodies. Among B2 cells in bPten (flox/flox) sp...

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Hlavní autoři: Suzuki, Akira, Kaisho, Tsuneyasu, Ohishi, Minako, Tsukio-Yamaguchi, Manae, Tsubata, Takeshi, Koni, Pandelakis A., Sasaki, Takehiko, Mak, Tak Wah, Nakano, Toru
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2003
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193827/
https://ncbi.nlm.nih.gov/pubmed/12615906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20021101
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