Cytosolic Phospholipase A(2)α–deficient Mice Are Resistant to Collagen-induced Arthritis

Pathogenic mechanisms relevant to rheumatoid arthritis occur in the mouse model of collagen-induced arthritis (CIA). Cytosolic phospholipase A(2)α (cPLA(2)α) releases arachidonic acid from cell membranes to initiate the production of prostaglandins and leukotrienes. These inflammatory mediators have...

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Detalhes bibliográficos
Main Authors: Hegen, Martin, Sun, Linhong, Uozumi, Naonori, Kume, Kazuhiko, Goad, Mary E., Nickerson-Nutter, Cheryl L., Shimizu, Takao, Clark, James D.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2193788/
https://ncbi.nlm.nih.gov/pubmed/12743172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030016
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