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Cytosolic Phospholipase A(2)α–deficient Mice Are Resistant to Collagen-induced Arthritis
Pathogenic mechanisms relevant to rheumatoid arthritis occur in the mouse model of collagen-induced arthritis (CIA). Cytosolic phospholipase A(2)α (cPLA(2)α) releases arachidonic acid from cell membranes to initiate the production of prostaglandins and leukotrienes. These inflammatory mediators have...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Rockefeller University Press
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2193788/ https://ncbi.nlm.nih.gov/pubmed/12743172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030016 |
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